The Most Popular Girls in School (abbreviated MPGIS) is an American stop-motion animated comedy web series that debuted on YouTube on May 1, 2012. Created by Mark Cope and Carlo Moss, the series animates Barbie, Ken and other fashion dolls, usually with customized costumes and hairstyles, as various characters. MPGIS follows the exploits of a fictional high school cheerleading team in Overland Park, Kansas and their friends, family and enemies. Variety described the series as "Mean Girls meets South Park".

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